Weight Loss Peptides in South Africa
This range is built around the incretin class: compounds that act on the receptors for GLP-1 and related gut hormones, which regulate appetite and blood sugar. Tirzepatide acts on two of them, GIP and GLP-1. Retatrutide adds a third, the glucagon receptor. Cagrilintide is an amylin analogue, a separate appetite pathway, studied both on its own and alongside semaglutide. These are the most heavily researched compounds on the site, with large human trials behind tirzepatide and published phase 2 data for retatrutide.
Alongside them sit compounds studied for fat metabolism by other routes. AOD-9604 is a fragment of growth hormone studied for fat breakdown. Tesamorelin is a GHRH analogue studied in clinical trials for visceral fat. 5-Amino-1MQ and SLU-PP-332 are earlier-stage compounds, studied in animal models for their effects on how cells use energy.
Two things are worth knowing in South Africa. Mounjaro, the registered tirzepatide medicine, is available on prescription, and most medical schemes do not fund GLP-1 drugs for weight loss; our articles on tirzepatide in South Africa and on medical aid cover explain both. And gastrointestinal effects in this class rise with dose, which is why the clinical trials increased doses slowly over weeks.
8 in stock · priced in rand · delivered across South Africa · research purposes only
Weight Loss & Metabolism: in stock
5-Amino-1MQ
Inhibits NNMT enzyme activity to promote fat loss and improved cellular metabolism.
SLU-PP-332
An ERR agonist studied in mice as an “exercise mimetic” for endurance and fat oxidation. There is no human data yet.
AOD-9604
A modified hGH fragment designed to keep growth hormone’s fat-burning signal without its effects on growth or blood sugar.
Tesamorelin
A GHRH analogue studied in clinical trials for reducing visceral fat, by raising the body’s own growth hormone release.
Green dot = in stock · others on request
Tesa10 + Ipamorelin Stack
Pre-combined Tesamorelin and Ipamorelin for optimised GH release with targeted visceral fat reduction.
Retatrutide
The most advanced weight loss peptide available: a triple agonist delivering superior fat reduction and metabolic control.
Green dot = in stock · others on request
Tirzepatide
Dual GIP/GLP-1 receptor agonist studied for weight loss and blood sugar control.
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Cagrilintide
A long-acting amylin analogue studied for appetite and weight, mostly with semaglutide as CagriSema.
Green dot = in stock · others on request
The research, in plain language
Semaglutide vs Tirzepatide vs Retatrutide
Semaglutide, Tirzepatide and Retatrutide compared: how each GLP-1 class peptide works, trial results, and which suits your weight loss goal.
Tirzepatide in South Africa: 2026 Guide
Tirzepatide is registered in South Africa as Mounjaro and approved for weight management. What it costs, how it compares to semaglutide and where it fits.
Does Medical Aid Cover Mounjaro or Ozempic?
Why most South African medical schemes do not cover Ozempic or Mounjaro for weight loss, what the PMB rules actually say, and the questions to ask your scheme.
GLP-1 Peptides Explained: How They Work
How GLP-1 peptides control appetite and metabolism, why they are so effective for weight loss, and what research says about long-term use.
AOD-9604 vs HGH Fragment 176-191 Compared
AOD-9604 and HGH Fragment 176-191 are closely related fat-loss peptides. How they compare, how they work and what the research says.