Semax Nasal Spray
Semax was developed as a nasal preparation in the first place — the spray is its native format, not an adaptation.
The ACTH-derived nootropic, researched for sustained attention, working memory and mental stamina.
1 bottle
10ml · 5mg
R 400
VAT inclusive · Shipped nationwide from Johannesburg · Research use only
What’s in each spray
The spray arrives already in solution, so the arithmetic is done for you. Figures assume a standard 0.1 mL metered pump.
Per bottle
5mg
in 10ml
Per mL
500mcg
concentration
Per spray
50mcg
at 0.1 mL a spray
Sprays
~100
per bottle, before priming
Why Semax as a nasal spray
Most peptides reach the market as injectables and are later tried intranasally. Semax went the other way. It was developed at the Russian Academy of Sciences as nasal drops, and the Russian clinical literature on it, stretching back to the 1980s, is overwhelmingly intranasal. When a paper describes what Semax does, it is usually describing what it does after going in through the nose.
The reasoning is anatomical. The upper nasal cavity sits directly beneath the brain, and the olfactory and trigeminal nerves that run through it offer peptides a route into the central nervous system that bypasses both the gut, which would digest them, and much of the blood-brain barrier. For a compound whose entire interest is its effect on the brain, that route is the point.
About Semax
Semax is a synthetic peptide originally developed in Russia as an analogue of a fragment of adrenocorticotropic hormone (ACTH 4–10), stripped of its hormonal activity while retaining its effects on the central nervous system. It is one of the most studied nootropic peptides in the research literature, with a body of work — mostly from Russian institutions — investigating its influence on brain-derived neurotrophic factor (BDNF) expression, attention, and neuroprotection following ischaemic events.
Research interest centres on sustained attention, working memory and mental stamina under cognitively demanding conditions. It has also been studied in the context of ADHD-type symptoms and post-stroke recovery, though these remain research contexts rather than approved clinical uses outside Russia.
Read the full Semax compound profileWhat the research covers
Published findings, not promised outcomes. Studies are listed under Sources below.
BDNF after a single intranasal dose
Dolotov and colleagues (2006) found a single intranasal application in rats raised hippocampal BDNF protein about 1.4-fold and activated its receptor, trkB — the mechanism most Semax research leans on.
Learning and memory in animal models
The same work recorded more conditioned avoidance responses in treated animals, the behavioural half of the BDNF finding and the basis of the focus and memory positioning.
Neuroprotection
Russian clinical use centres on stroke and cerebral circulation. That work is largely published in Russian journals, which is why it is cited less often outside Russia than its volume would suggest.
Where the evidence is thin
Most of the Semax literature comes from a small number of Russian institutions, much of it in animals, and it has had little independent replication in Western trials. That is not the same as evidence against it, but it is a narrower base than the confidence of most online write-ups implies.
Spray, vial or pen
Semax comes in all three formats. The compound is the same; what changes is the preparation and how it goes in.
Nasal spray
This pageR 400
10ml · 5mg
- Preparation
- Ready to use
- Delivery
- Intranasal, no needles
Using a nasal spray properly
- 1
Prime the pump
Before the first use, pump into the air until a fine, even mist comes out. Those first few sprays are not counted in the bottle total.
- 2
Clear your nose
Blow your nose gently first. A congested nose absorbs poorly and more of the spray runs straight out.
- 3
Aim away from the middle
Tilt your head slightly forward and point the nozzle toward the outer wall of the nostril, not the septum.
- 4
Breathe in gently
Press once while breathing in softly through the nose. A hard sniff pulls the spray down the throat instead of leaving it in the nose.
- 5
Alternate nostrils
Between sprays, alternate nostrils. That spreads the dose over more of the nasal lining.
Storage
Keep the bottle upright with the cap on, and in the fridge once opened. The amber glass protects the solution from light, but not from heat: don’t leave it in a parked car or a sunny window, especially in a South African summer. Don’t freeze it, and don’t share a nozzle between people.
Questions about the Semax spray
Order Semax Nasal Spray in South Africa
Add it to your order slip and send it when you’re ready. We’ll confirm stock, pricing and delivery on WhatsApp before you pay a cent.
For Research Use Only — not for human consumption.