Melanotan II
The melanocortin agonist known for tanning, with two other effects that are the reason plenty of people buy it.
A melanocortin agonist studied in small 1990s trials for skin darkening and erections; PT-141 was later developed from it.
- Also known as
- MT-II
- Class
- Synthetic alpha-MSH analogue (non-selective melanocortin receptor agonist)
- Evidence
- Early human studies
- FDA
- Not approved anywhere
- WADA 2026
- Not named; likely covered by S0 (substances not approved for human use anywhere are prohibited at all times)
Concentrations · 1 vial
R 40010mg selected — in stock and shipping now.
About Melanotan II
Melanotan II is a synthetic analogue of alpha-melanocyte-stimulating hormone. It binds melanocortin receptors and stimulates melanin production, which is where the tanning reputation comes from — it is the compound behind the entire "tanning peptide" category. But it binds several melanocortin receptors rather than one, and the other two it hits are the reason the product description mentions appetite and libido alongside pigmentation.
That breadth is both the appeal and the caveat. Melanotan II is less selective than PT-141, which was developed from the same family specifically to isolate the arousal effect. If sexual health is the goal, PT-141 is the targeted tool. If tanning is the goal, this is the compound with the research behind it.
Specifications
Evidence level: Early human studies · Small pilot trials in the 1990s, plus published case reports of harm.
- Formula
- C50H69N15O9 PubChem ↗
- Molecular weight
- 1024.2 g/mol
- CAS number
- 121062-08-6
What it’s researched for
Research context, not medical advice. Everything we sell is supplied for research purposes.
Melanin production
The primary research interest and the reason the compound exists: stimulating melanocytes directly rather than through UV exposure.
Appetite suppression
A documented melanocortin effect, and a reason Melanotan II occasionally appears in weight protocols despite not being marketed as one.
Libido
The effect PT-141 was developed to isolate. Present here, alongside everything else, rather than on its own.
What the research does not show
The limits of the evidence, stated as plainly as the findings.
- An established safety profile. Dermatology journals have reported changing moles and melanoma linked to unregulated use.
Reconstitution and storage
The 10mg vial with 2 mL of bacteriostatic water gives 5mg/mL. Unopened vials are stable at room temperature in transit but belong in a fridge once they arrive, and out of a parked car in a Highveld summer.
Questions we get about Melanotan II
Sources
- Wessells H, Levine N, et al. Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. International Journal of Impotence Research, 2000.
- Wessells H, Gralnek D, et al. Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology, 2000.
- Evans-Brown M, Dawson RT, et al. Use of melanotan I and II in the general population. BMJ, 2009.
- Paurobally D, Jason F, et al. Melanotan-associated melanoma. The British Journal of Dermatology, 2011.
Often bought with it
Order Melanotan II in South Africa
Everything ships from Johannesburg, nationwide. Add it to your order slip, send the slip on WhatsApp, and we’ll confirm stock, pricing and delivery before you pay a cent.